Milrinone.com (Primacor®) Home Page

Welcome to The Milrinone Source, an interactive web site intended for US audiences. This web site is designed

for physicians and other health care personnel who want information on important and new aspects of milrinone (Primacor®).

Milrinone is a newer cyclic AMP specific phosphodiesterase (PDE) inhibitor (also called Fraction III or low-K_m cyclic AMP) that can produce both positive inotropic

effects and vasodilation independent of ß₁-adrenergic receptor stimulation in the

cardiovascular system. Milrinone improves hemodynamics and biventricular function in patients with ventricular dysfunction by increasing stroke volume index, increasing left ventricular contractility, producing pulmonary vasodilation. Milrinone also produces vasodilation in arteriolar and venous vascular smooth muscle. Compared to amrinone, another bipyridine derivative, milrinone is a more potent drug with a much shorter context sensitive half time (duration of action) and fewer side effects.

This site is sponsored by DocMD.com, a new internet site dedicated to bringing useful information to physicians and other health care personnel. Be sure to visit DocMD.com to keep up on what is new and interesting in healthcare, and for other useful information.